Transmission-based association mapping of triglyceride levels in a longitudinal framework using quasi-likelihood

• DOI: 10.1186/s12919-018-0147-4
• Publication Date: 2018-09-17T07:18:36Z
• Authors: Hemant Kulkarni; Indranil Mukhopad...; Saurabh Ghosh
• Keywords: Association (psychology); Genetic Association; Fenofibrate; Genome-wide Association Study; Association test

Complex genetic traits are often characterized by multiple quantitative phenotypes. Because values of such phenotypes vary over time, it is thought that analyses longitudinal data on the may lead to increased power in detecting association. In this paper, we extend a transmission-based association test applying quasi-likelihood has been developed us framework and carry out genome-wide analysis triglyceride levels based provided GAW20. We consider different phenotype definitions administration fenofibrate obtain significant findings within genes involved heart diseases.