Dynamic modulations of urinary sphingolipid and glycerophospholipid levels in COVID-19 and correlations with COVID-19-associated kidney injuries

• DOI: 10.1186/s12929-022-00880-5
• Publication Date: 2022-11-10T09:03:33Z
• Authors: Makoto Kurano; Daisuke Jubishi; Koh Okamoto; Hideki Hashimoto; Eri Sakai; Yoshifumi Morita; Daisuke Saigusa; Kuniyuki Kano; Junken Aoki; Sohei Harada; Shu Okugawa; Kent Doi; Kyoji Moriya; Yutaka Yatomi
• Keywords: Lysophosphatidylethanolamine; Sphingolipid; Phosphatidylethanolamine; Phosphatidylglycerol

Among various complications of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome 2 (SARS-CoV-2), renal complications, namely COVID-19-associated kidney injuries, are related to the mortality COVID-19.In this retrospective cross-sectional study, we measured sphingolipids and glycerophospholipids, which have been shown possess potent biological properties, using liquid chromatography-mass spectrometry in 272 urine samples collected longitudinally from 91 COVID-19 subjects 95 control without infectious diseases, elucidate pathogenesis injuries.The urinary levels C18:0, C18:1, C22:0, C24:0 ceramides, sphingosine, dihydrosphingosine, phosphatidylcholine, lysophosphatidylcholine, lysophosphatidic acid, phosphatidylglycerol decreased, while those phosphatidylserine, lysophosphatidylserine, phosphatidylethanolamine, lysophosphatidylethanolamine increased patients with mild COVID-19, especially during early phase (day 1-3), suggesting that these modulations might reflect direct effects infection SARS-CoV-2. Generally, sphingomyelin, dihydrosphingosine L-phosphate, lysophosphatidylethanolamine, phosphatidylglycerol, lysophosphatidylglycerol, phosphatidylinositol, lysophosphatidylinositol increased, later phase, their result injuries accompanying COVID-19.Considering properties an understanding will help us understand mechanisms causing as well general may prompt researchers develop laboratory tests for predicting maximum severity and/or novel reagents suppress COVID-19.