Preserved ratio impaired spirometry is associated with small airway dysfunction and reduced total lung capacity

• DOI: 10.1186/s12931-022-02216-1
• Publication Date: 2022-10-31T10:02:56Z
• Authors: Ningning Zhao; Fan Wu; Jieqi Peng; Youlan Zheng; Heshen Tian; Huajing Yang; Zhishan Deng; Zihui Wang; Haiqing Li; Xiang Wen; Shan Xiao; Peiyu Huang; Cuiqiong Dai; Lifei Lu; Kunning Zhou; Shengtang Chen; Yumin Zhou; Pixin Ran
• Keywords: Vital capacity

Abstract Background: Preserved ratio impaired spirometry (PRISm) refers to decreased forced expiratory volume in 1 s (FEV ) the setting of preserved ratio. Little is known about role PRISm and its complex relation with small airway dysfunction (SAD) lung volume. Therefore, we aimed investigate associations between SAD Methods: We conducted a cross-sectional community-dwelling study China. Demographic data, standard respiratory epidemiology questionnaire, spirometry, impulse oscillometry (IOS) computed tomography (CT) data were collected. was defined as post-bronchodilator FEV /FVC ≥ 0.70 < 80% predicted. Spirometry-defined at least two three maximal mid-expiratory flow (MMEF), 50% (FEF50), 75% (FEF75) less than 65% IOS-defined CT-defined gas trapping by fact that cutoff value peripheral resistance R5–R20 > 0.07 kPa/L/s LAA − 856 >20%, respectively. Analysis covariance logistic regression used determine then repeated analysis lower limit normal definition criteria FVC PRISm. Moreover, also performed subgroup analyses ever smoker, never subjects without reversibility or self-reported diagnosed asthma, CT-measured total capacity ≥70% Results: The final included 1439 subjects. had higher odds more severity spirometry-defined (pre-bronchodilator: [OR]: 5.99, 95% confidence interval [95%CI]: 3.87–9.27, P 0.001; post-bronchodilator: OR: 14.05, 95%CI: 8.88–22.24, 0.001), (OR: 2.89, 1.82–4.58, CT-air 2.01, 1.08–3.72, = 0.027) compared healthy control after adjustment for confounding factors. controls (4.15 ± 0.98 vs. 4.78 1.05 L, 0.05), adjustment. These results robust repeating analyses. Conclusion: Our finding revealed associated reduced capacity. Future studies identify underlying mechanisms longitudinal progression are warranted.