Circulating adiponectin and cardiovascular mortality in patients with type 2 diabetes mellitus: evidence of sexual dimorphism

• DOI: 10.1186/s12933-014-0130-y
• Publication Date: 2014-09-09T08:22:20Z
• Authors: Claudia Menzaghi; Min Xu; Lucia Salvemini; Concetta De Bonis; Giuseppe Palladino; Tao Huang; Massimiliano Copetti; Yan Zheng; Yanping Li; Grazia Fini; Frank B Hu; Simonetta Bacci; Lu Qi; Vincenzo Trischitta
• Keywords: Angiology; Sexual dimorphism

The pathogenesis of cardiovascular (CV) mortality, whose rate is increased in type 2 diabetes, poorly understood. While high serum adiponectin associated with CV mortality the general population, no data are available diabetes. We here investigated whether this counterintuitive association was observable also diabetic patients and it sex-specific. Three prospective cohorts were analyzed: 1) Gargano Heart Study (GHS; 359 patients, 58 events/1,934 person-years; py); 2) Health Professional Follow-up (HPFS; 833 men, 146 events/10,024 3) Nurses' (NHS; 902 women, 144 events/15,074 py). In GHS predicted men (hazard ratio, HR, 95% CI per standard deviation, SD, increment = 1.54, 1.19-2.01), but not women (HR 0.98, 0.48-2.01). Circulating from HPFS 1.44, 1.21-1.72), NHS 1.08, 0.86-1.35), used as replication samples. a pooled analysis, HRs 1.47 (1.27-1.70) 1,075 1.07 (0.86-1.33) 1,019 (p for heterogeneity across sexes 0.018). This first report showing that circulating predicts Further studies necessary to unravel mechanisms through which influences sex-specific manner.