The protective effect of the Mediterranean diet on endothelial resistance to GLP-1 in type 2 diabetes: a preliminary report

• DOI: 10.1186/s12933-014-0140-9
• Publication Date: 2014-11-21T06:04:24Z
• Authors: Antonio Ceriello; Katherine Esposito; Lucia La Sala; Gemma Pujadas; Valeria De Nigris; Roberto Testa; Loredana Bucciarelli; Maurizio Rondinelli; Stefano Genovese
• Keywords: Mediterranean Diet; Nitrotyrosine; Endothelial Dysfunction

In type 2 diabetes, acute hyperglycemia worsens endothelial function and inflammation,while resistance to GLP-1 action occurs. All these phenomena seem be related the generation of oxidative stress. A Mediterranean diet, supplemented with olive oil, increases plasma antioxidant capacity, suggesting that its implementation can have a favorable effect on aforementioned phenomena. present study, we test hypothesis diet using oil counteract effects improve endothelium action. Two groups diabetic patients, each consisting twelve subjects, participated in randomized trial for three months, following or control low-fat diet. Plasma function, nitrotyrosine, 8-iso-PGF2a, IL-6 ICAM-1 levels were evaluated at baseline end study. The during hyperglycemic clamp, was also studied Compared increased capacity improved basal levels. reduced negative hyperglycemia, induced by Furthermore, protective levels, increasing GLP-1-induced insulin secretion. These data suggest prevents inflammation stress, improves GLP-1, which may management particularly prevention cardiovascular disease.