The ratio of skeletal muscle mass to visceral fat area is a main determinant linking circulating irisin to metabolic phenotype

• DOI: 10.1186/s12933-015-0319-8
• Publication Date: 2016-01-20T03:50:36Z
• Authors: You-Cheol Hwang; Won Seon Jeon; Cheol-Young Park; Byung-Soo Youn
• Keywords: Myokine; Angiology

The aims of this study were to investigate whether circulating irisin is associated with favorable metabolic parameters and how the association differs according body composition in humans. A total 424 subjects (233 men 191 women), aged 23–73 years (mean age 47.1 years), enrolled from Seoul Metro City Diabetes Prevention Program. Body was determined using an impedance analyzer, serum level measured a commercial kit. Serum correlated including less obese, lower blood pressure glucose levels healthy lipid parameters. skeletal muscle mass visceral fat area ratio (SVR) positively concentration (r = 0.10, P 0.04). When divided into tertiles their SVR, phenotypes those upper tertile. However, there no such correlations In addition, inversely related pre-diabetes/type 2 diabetes (T2D) independent other risk factor for T2D insulin resistance [OR (95 % CI); 0.66 (0.49–0.90), 0.009]. compositions play key roles between patient's phenotype.