Circulating angiopoietin-like protein 8 (ANGPTL8) and ANGPTL3 concentrations in relation to anthropometric and metabolic profiles in Korean children: a prospective cohort study

• DOI: 10.1186/s12933-015-0324-y
• Publication Date: 2016-01-05T23:44:46Z
• Authors: Hye Soo Chung; Min Jung Lee; Soon Young Hwang; Hyun Jung Lee; Hye Jin Yoo; Ji-A Seo; Sin Gon Kim; Nan Hee Kim; Sei Hyun Baik; Dong Seop Choi; Seon Mi Kim; Kyung Mook Choi
• Keywords: Energy homeostasis

Previous studies have shown that angiopoietin-like protein 8 (ANGPTL8), also called as betatrophin, acts together with ANGPTL3 to regulate lipid metabolism, glucose and energy homeostasis. Moreover, ANGPTL8 promotes proliferation of pancreatic β-cells induces insulin secretion. However, there are no previous longitudinal in humans.We analyzed the age- sex-matched data 240 normal weight overweight Korean children from Metabolic disorders Obesity Study Elementary School (K-MOSES), a prospective observational cohort study.At baseline, concentrations were positively associated triglycerides (TG) (r = 0.168, P 0.010), whereas levels fasting 0.248, < 0.001) homeostasis model assessment resistance (HOMA-IR) 0.197, 0.002). Although both did not differ between overweight, increased males compared females (341.2 [267.4-436.5] vs. 270.2 [213.9-378.8] pg/ml, 0.001). In particular, was significant inter-relationship circulating boys girls -0.073, 0.265). Multivariate analysis showed baseline independently future changes serum TG after adjusting for confounding factors 3 year follow-up period -0.165, 0.016).This study demonstrated first time children.