Low and exacerbated levels of 1,5-anhydroglucitol are associated with cardiovascular events in patients after first-time elective percutaneous coronary intervention

• DOI: 10.1186/s12933-016-0459-5
• Publication Date: 2016-10-11T04:15:22Z
• Authors: Shuhei Takahashi; Kazunori Shimada; Katsumi Miyauchi; Tetsuro Miyazaki; Eiryu Sai; Manabu Ogita; Shuta Tsuboi; Hiroshi Tamura; Shinya Okazaki; Tomoyuki Shiozawa; Shohei Ouchi; Tatsuro Aikawa; Tomoyasu Kadoguchi; Hamad Al Shahi; Takuma Yoshihara; Makoto Hiki; Kikuo Isoda; Hiroyuki Daida
• Keywords: Angiology

Postprandial hyperglycemia plays an important role in the pathogenesis of coronary artery disease and cardiovascular events. Serum 1,5-anhydroglucitol (1,5-AG) levels are known to be a clinical marker postprandial hyperglycemia. However, impact 1,5-AG level on events has not been fully investigated. We enrolled 240 consecutive patients who had undergone first-time elective percutaneous intervention (PCI) with follow-up angiography within 1 year. excluded history acute syndrome, advanced chronic kidney (estimated glomerular filtration rate <30 mL/min/1.73 m2), or uncontrolled diabetes mellitus (HbA1c ≥7.0%). Fasting blood glucose (FBS), HbA1c, were measured prior PCI at time angiography. Clinical events, including target lesion revascularization, vessel revascularization new lesions, evaluated. Subjects divided into two groups according outcomes: Event (+) group (n = 40) (−) 200). No significant differences observed, except for number diseased vessels prevalence statin use, baseline characteristics between groups. significantly lower than (P 0.02). A reduction from was observed compared 0.04). The association remained after adjustment independent variables, FBS HbA1c Low exacerbated associated present study, indicating that is risk factor adverse even < 7.0%, following PCI.