Metabolic syndrome is independently associated with increased 20-year mortality in patients with stable coronary artery disease

• DOI: 10.1186/s12933-016-0466-6
• Publication Date: 2016-10-28T10:16:38Z
• Authors: Arwa Younis; Anan Younis; Boaz Tzur; Yael Peled; Nir Shlomo; Ilan Goldenberg; Enrique Z. Fisman; Alexander Tenenbaum; Robert Klempfner
• Keywords: Male; Endocrinology, Diabetes and Metabolism; Coronary Artery Disease; Kaplan-Meier Estimate; Risk Assessment; 03 medical and health sciences; 0302 clinical medicine; Humans; Registries; Renal Insufficiency; Original Investigation; Aged; Hypolipidemic Agents; Proportional Hazards Models; Randomized Controlled Trials as Topic; Retrospective Studies; Metabolic Syndrome; Chi-Square Distribution; Age Factors; Middle Aged; Prognosis; 3. Good health; Multivariate Analysis; Female; Bezafibrate; Cardiology and Cardiovascular Medicine

Data regarding long-term association of metabolic syndrome (MetS) with adverse outcomes are conflicting. We aim to determine the independent MetS (based on its different definitions) 20 year all-cause mortality among patients stable coronary artery disease (CAD).Our study comprised 15,524 who were enrolled in Bezafibrate Infarction Prevention registry between February 1, 1990, and October 31, 1992, subsequently followed-up for through December 2014. was defined according two definitions: The International Diabetes Federation (IDF); National Cholesterol Education Program-Third Adult Treatment Panel (NCEP).According IDF criteria 2122 (14%) had MetS, whereas NCEP definition 7446 (48%) MetS. Kaplan-Meier survival analysis showed that significantly higher by both (67 vs. 61%; log rank-p < 0.001) as well 54%; criteria. Multivariate adjusted risk 17% greater [Hazard Ratio (HR) 1.17; 95% Confidence Interval (CI) 1.07-1.28] 21% (HR 1.21; CI 1.13-1.29) using definition. Subgroup demonstrated increased associated consistent most clinical subgroups excepted renal failure (p value interaction 0.05).Metabolic is independently an 20-year CAD. This when either or definitions used. Trial registration retrospective registered.