Impaired ventricular filling limits cardiac reserve during submaximal exercise in people with type 2 diabetes

• DOI: 10.1186/s12933-017-0644-1
• Publication Date: 2017-12-18T23:57:27Z
• Authors: Genevieve A. Wilson; Gerard T. Wilkins; Jim D. Cotter; Regis R. Lamberts; Sudish Lal; James C. Baldi
• Keywords: Aerobic Exercise; Angiology

Attenuated increases in ventricular stroke volume during exercise are common type 2 diabetes and contribute to reduced aerobic capacity. The purpose of this study was determine whether impaired filling or systolic ejection were responsible for the attenuated reserve people with uncomplicated diabetes. Peak capacity total blood measured 17 16 non-diabetic controls no evidence cardiovascular disease. Left volumes other diastolic functional parameters echocardiography at rest semi-recumbent cycle ergometry 40 60% maximal power compared between groups. People had peak heart rate reserve, worked lower workloads than controls. Cardiac output, fraction not different rest, but increased less exercise. end groups any condition volume, although smaller Total groups, only moderately associated left volumes. exhibit an increase attributed inability maintain/increase higher rates. This is first role blunted cardiac adults