Glycemic variability in continuous glucose monitoring is inversely associated with baroreflex sensitivity in type 2 diabetes: a preliminary report

• DOI: 10.1186/s12933-018-0683-2
• Publication Date: 2018-03-07T08:01:47Z
• Authors: Daisuke Matsutani; Masaya Sakamoto; Hiroyuki Iuchi; Souichirou Minato; Hirofumi Suzuki; Yosuke Kayama; Norihiko Takeda; Ryuzo Horiuchi; Kazunori Utsunomiya
• Keywords: Angiology; Coefficient of variation

Abstract Background It is presently unclear whether glycemic variability (GV) associated with baroreflex sensitivity (BRS), which an early indicator of cardiovascular autonomic neuropathy. The present study the first to examine relationships between BRS and GV measured using continuous glucose monitoring (CGM). Methods This was a multicenter, prospective, open-label clinical trial. A total 102 patients type 2 diabetes were consecutively recruited for this study. assessed by measuring standard deviation (SD), coefficient variation (CV), mean amplitude excursions (MAGE) during CGM. analyzed from electrocardiogram blood pressure recordings sequence method on day hospitalization. Results 94 (mean duration 9.7 ± 9.6 years, HbA1c 61.0 16.8 mmol/mol [7.7 1.5%]) analyzed. In univariate analysis, CGM-SD ( r = − 0.375, p 0.000), CGM-CV 0.386, MAGE 0.395, 0.000) inversely related BRS. addition GV, level correlated in R–R intervals (CVR-R) 0.520, heart rate (HR) 0.310, 0.002), cardio-ankle vascular index (CAVI) 0.326, 0.001), age 0.519, estimated glomerular filtration (eGFR) 0.276, 0.007). Multiple regression analysis showed that significantly decrease These findings remained after adjusting age, sex, hypertension, dyslipidemia, HR, eGFR, CAVI, CGM-mean glucose. Additionally, divided according quartiles (Q1–4). decreased 2-year independently sex. Conclusions levels diabetic patients. Measurement may have potential predict CV events consideration GV. Trial registration UMIN Clinical Trials Registry UMIN000025964, 28/02/2017