Childhood retinol-binding protein 4 (RBP4) levels predicting the 10-year risk of insulin resistance and metabolic syndrome: the BCAMS study

• DOI: 10.1186/s12933-018-0707-y
• Publication Date: 2018-05-14T03:27:36Z
• Authors: Ge Li; Issy C. Esangbedo; Lu Xu; Junling Fu; Lujiao Li; Dan Feng; Lanwen Han; Xinhua Xiao; Mingyao Li; Jie Mi; Ming Li; Shan Gao; Steven M. Willi
• Keywords: Male; 0301 basic medicine; China; Youth; Time Factors; Adolescent; Risk Assessment; Decision Support Techniques; 03 medical and health sciences; Retinol-binding protein 4; Predictive Value of Tests; Risk Factors; Diseases of the circulatory (Cardiovascular) system; Humans; Longitudinal Studies; Prospective Studies; Child; Children; Original Investigation; Metabolic Syndrome; Incidence; Age Factors; Insulin resistance; Metabolic syndrome; 3. Good health; Cross-Sectional Studies; RC666-701; Female; Insulin Resistance; Retinol-Binding Proteins, Plasma; Biomarkers

Elevated retinol-binding protein 4 (RBP4) levels may contribute to the development of metabolic abnormalities, but prospective studies evaluating association between childhood RBP4 and syndrome (MS) in adulthood are lacking. We investigated whether during predict cardiometabolic risk at 10-year follow-up. The relationships levels, established adipokines (leptin adiponectin) components MS were examined 3445 school-aged children recruited 2004 for Beijing Child Adolescent Metabolic Syndrome study. In 2015, 352 these individuals completed an in-depth follow-up examination. Participants with higher had adverse profiles Those incident or persistent baseline than those who never exhibited elements MS. Moreover, predicted hyperglycemia (OR per SD increase = 1.48, P 0.009), elevated triglyceride 1.54, < 0.001), blood pressures 1.46, 0.015), 1.68, 0.002) insulin resistance 1.44, 0.015) phase, independent BMI. Significant improvements seen net reclassification improvement integrated discrimination index after adding into models using conventional factors predicting (P 0.05). Leptin adiponectin demonstrated expected associations disorders. Childhood serves as a factor subsequent its components, pediatric obesity. Incorporating assessment significantly improves prediction