Childhood retinol-binding protein 4 (RBP4) levels predicting the 10-year risk of insulin resistance and metabolic syndrome: the BCAMS study
Male
0301 basic medicine
China
Youth
Time Factors
Adolescent
Risk Assessment
Decision Support Techniques
03 medical and health sciences
Retinol-binding protein 4
Predictive Value of Tests
Risk Factors
Diseases of the circulatory (Cardiovascular) system
Humans
Longitudinal Studies
Prospective Studies
Child
Children
Original Investigation
Metabolic Syndrome
Incidence
Age Factors
Insulin resistance
Metabolic syndrome
3. Good health
Cross-Sectional Studies
RC666-701
Female
Insulin Resistance
Retinol-Binding Proteins, Plasma
Biomarkers
DOI:
10.1186/s12933-018-0707-y
Publication Date:
2018-05-14T03:27:36Z
AUTHORS (13)
ABSTRACT
Elevated retinol-binding protein 4 (RBP4) levels may contribute to the development of metabolic abnormalities, but prospective studies evaluating association between childhood RBP4 and syndrome (MS) in adulthood are lacking. We investigated whether during predict cardiometabolic risk at 10-year follow-up. The relationships levels, established adipokines (leptin adiponectin) components MS were examined 3445 school-aged children recruited 2004 for Beijing Child Adolescent Metabolic Syndrome study. In 2015, 352 these individuals completed an in-depth follow-up examination. Participants with higher had adverse profiles Those incident or persistent baseline than those who never exhibited elements MS. Moreover, predicted hyperglycemia (OR per SD increase = 1.48, P 0.009), elevated triglyceride 1.54, < 0.001), blood pressures 1.46, 0.015), 1.68, 0.002) insulin resistance 1.44, 0.015) phase, independent BMI. Significant improvements seen net reclassification improvement integrated discrimination index after adding into models using conventional factors predicting (P 0.05). Leptin adiponectin demonstrated expected associations disorders. Childhood serves as a factor subsequent its components, pediatric obesity. Incorporating assessment significantly improves prediction
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