Remnant lipoproteins play an important role of in-stent restenosis in type 2 diabetes undergoing percutaneous coronary intervention: a single-centre observational cohort study

• DOI: 10.1186/s12933-019-0819-z
• Publication Date: 2019-01-28T08:02:44Z
• Authors: Zheng Qin; Kuo Zhou; Yue-ping Li; Jian-long Wang; Wan-jun Cheng; Cheng-ping Hu; Chao Shi; Hua He; Yu-jie Zhou
• Keywords: In-stent restenosis; Male; Lipoproteins; Cholesterol, VLDL; Coronary Artery Disease; Coronary Angiography; Risk Assessment; Percutaneous coronary intervention; Coronary Restenosis; 03 medical and health sciences; Percutaneous Coronary Intervention; 0302 clinical medicine; Risk Factors; Type 2 diabetes mellitus; Remnant-like particle cholesterol; Diseases of the circulatory (Cardiovascular) system; Humans; Original Investigation; Aged; Retrospective Studies; Remnant lipoproteins; Cholesterol, LDL; Middle Aged; 3. Good health; Cholesterol; Diabetes Mellitus, Type 2; RC666-701; Beijing; Female; Stents; Very-low-density lipoprotein cholesterol; Biomarkers

Increasing evidence has suggested that the presence of remnant lipoproteins is a significant risk factor for atherosclerosis. Remnant are rich in triglycerides (TGs), and main components include very-low-density lipoprotein (VLDL) fasting state. Diabetic patients often have hypertriglyceridemia with elevated levels VLDL cholesterol but normal low-density (LDL-C). The aim present study was to elucidate potential role lipoproteins-induced atherosclerosis occurrence development in-stent restenosis (ISR) diabetic coronary artery disease. enrolled 2312 type 2 diabetes mellitus who underwent percutaneous intervention from January 2013 December 2014 were followed up by angiography. Patients divided into two groups based on or absence ISR, multivariate Cox’s proportional hazards regression modelling showed remnant-like particle (RLP-C) an independent ISR. According receiver operating characteristic curve, optimal cutoff point RLP-C identified, further groups. Propensity score matching analysis performed, 762 pairs successfully matched. Log-rank tests used compare Kaplan–Meier curves overall follow-up assess independently associated baseline level at 0.505 mmol/L identified as predict RLP levels. After propensity analysis, total matched generated. estimated cumulative rate ISR significantly higher ≥ (log-rank P < 0.001; HR equal 4.175, 95% CI = 3.045–5.723, 0.001) compared mmol/L. emphasized importance cardiovascular pathology patients. Physicians should take measures control below better prevent