Insulin resistance and dysglycemia are associated with left ventricular remodeling after myocardial infarction in non-diabetic patients

• DOI: 10.1186/s12933-019-0904-3
• Publication Date: 2019-08-07T12:02:53Z
• Authors: Chen Die Yang; Ying Shen; Lin Lu; Feng Hua Ding; Zhen Kun Yang; Rui Yan Zhang; Wei Feng Shen; Wei Jin; Xiao Qun Wang
• Keywords: Angiology; Ventricular remodeling; Diabetic Cardiomyopathy; Myocardial infarction complications

Abstract Background Adverse cardiac remodeling after ST-segment elevation myocardial infarction (STEMI) is a major cause for poor cardiovascular outcomes such as heart failure. The predisposing factors and underlying mechanisms remain not fully understood. This study investigates the association of insulin resistance dysglycemia with left ventricular (LV) STEMI in non-diabetic patients. Methods A total 485 subjects who underwent primary percutaneous coronary intervention were consecutively enrolled followed up 12 months. Relation homeostasis model assessment-estimated (HOMA-IR) glucose levels to changes echocardiography parameters was studied. Results Left dilation detected 49.1% at 12-month follow-up STEMI, more severe impaired fasting (IFG), tolerance (IGT) high HOMA-IR levels. remained correlated LV dimensions adjusting confounding risk factors. Multivariate regression analysis demonstrated that higher independently associated greater STEMI. significant interaction term present between IGT ( P = 0.001). Conclusions Our reveals are prevalent patients predictors post-infarction dilation. Trial registration Trials number, NCT02089360; registered on March 17, 2014