Association of circulating proprotein convertase subtilisin/kexin type 9 levels and the risk of incident type 2 diabetes in subjects with prediabetes: a population-based cohort study

• DOI: 10.1186/s12933-020-01185-3
• Publication Date: 2020-12-10T09:06:07Z
• Authors: Jie Shi; Weiwei Zhang; Yixin Niu; Ning Lin; Xiaoyong Li; Hongmei Zhang; Renming Hu; Guang Ning; Jiangao Fan; Li Qin; Qing Su; Zhen Yang
• Keywords: Prediabetes; PCSK9

Abstract Background Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates cholesterol metabolism by targeting the low-density lipoprotein receptor. Recent studies have shown that circulating PCSK9 is associated with glucose homeostasis and insulin resistance. The aim of this study was to examine association levels risk for development 2 diabetes in individuals prediabetes. Methods A population-based prospective conducted among 4205 Chinese subjects prediabetes (average age 56.1 ± 7.5 years). Incident diagnosed according 2010 American Diabetes Association criteria. Circulating were measured using a commercially available enzyme-linked immunosorbent assay (ELISA). incident assessed Cox regression analysis. Results During median follow-up period 3.1 years, 568 developed diabetes. Baseline significantly higher female developing than those not (p < 0.001). In subjects, highest quartile group (hazard ratio 2.16; 95% confidence interval 1.16–4.04) lowest after adjustments age, body mass index, waist circumference, C-reactive protein, γ-glutamyltransferase, triglycerides, cholesterol, systolic blood pressure, homeostatic model assessment resistance score. No significant observed between male subjects. Conclusion Elevated are an increased incidence