Short and long-term prognosis of admission hyperglycemia in patients with and without diabetes after acute myocardial infarction: a retrospective cohort study

• DOI: 10.1186/s12933-022-01550-4
• Publication Date: 2022-06-23T14:03:36Z
• Authors: Hanzohra Upur; Jia-Li Li; Xiao-Guang Zou; Yu-Ying Hu; He-Yin Yang; Alimujiang Abudou...; Anwar Abliz; Mamatili Abdukerim; Min Huang
• Keywords: Mace; Angiology

Abstract Objective Admission hyperglycemia is associated with poor prognosis in patients acute myocardial infarction (AMI), but the effects of baseline diabetes status on this association remain elusive. We aim to investigate impact admission short and long-term outcomes diabetic non-diabetic AMI patients. Methods In retrospective cohort study, 3330 regard first-time between July 2012 2020 were identified. Participants divided into two groups according (1060 2270 patients). Thereafter, they four status-specific cutoff values fasting blood glucose (FBG) identified by restricted cubic spline. Short-term included in-hospital death cardiac complications. Long-term all-cause mortality major adverse cardiovascular events (MACE). Inverse probability treatment weighting (IPTW) was conducted adjust for differences among groups, followed a weighted Cox proportional hazards regression analysis calculate hazard ratios 95% confidence intervals each FBG category. Subgroup sensitivity performed test robustness our findings. Results During median follow-up 3.2 years, 837 died. There significant interaction levels during (p-interaction < 0.001). Moreover, spline curves J shape non-linear without diabetes. Kaplan–Meier demonstrated greater survival non-hyperglycemia compared both groups. Survival than Multivariable cox analysis, predicted higher mortality. showed results. Conclusions The inflection points level 5.60 mmol/L 10.60 as an independent predictor worse patients, or These findings should be explored further.