High triglyceride-glucose index in young adulthood is associated with incident cardiovascular disease and mortality in later life: insight from the CARDIA study

• DOI: 10.1186/s12933-022-01593-7
• Publication Date: 2022-08-12T14:05:03Z
• Authors: Xinghao Xu; Rihua Huang; Yifen Lin; Yue Guo; Zhenyu Xiong; Xiangbin Zhong; Xiaomin Ye; Miaohong Li; Xiaodong Zhuang; Xinxue Liao
• Keywords: Angiology

Abstract Background This study aimed to investigate the associations between triglyceride-glucose (TyG) index in young adulthood with incident cardiovascular disease (CVD) and mortality. Methods We included 4,754 participants from Coronary Artery Risk Development Young Adults at baseline. The TyG was calculated as ln (fasting TG [mg/dl] × fasting glucose [mg/dl]/2), trajectories were identified by using latent class growth mixture model. evaluated association baseline of CVD events all-cause mortality Cox proportional hazards regression analysis. added value pooled cohort equations for prediction also analyzed. Results Among 4754 (mean age 24.72 years, 45.8% male, 51.2% black), there 158 246 during a median 25 years follow-up. After adjusting multiple confounding variables, each one-unit increase associated 96% higher risk (hazard ratio [HR] 1.96, 95% confidence interval [CI] 1.44–2.66) 85% (HR 1.85, CI 1.45–2.36). Three distinct along follow-up duration identified: low (44.0%), moderate (45.5%), high (10.5%). Compared those trajectory group, group had greater 2.35, 1.34–4.12) 3.04, 1.83–5.07). addition improved C-statistics (P < 0.001), integrated discrimination improvement category-free net reclassification = 0.003). Conclusions Higher levels long-term significantly an increased later life.