The change of triglyceride-glucose index may predict incidence of stroke in the general population over 45 years old

• DOI: 10.1186/s12933-023-01870-z
• Publication Date: 2023-06-09T13:02:09Z
• Authors: Yaoling Wu; Yongbiao Yang; Jinsheng Zhang; Shuo Liu; Weiduan Zhuang
• Keywords: Stroke

Stroke has been found to be highly correlated with the triglyceride-glucose (TyG) index. The relation between TyG index changes and stroke, however, seldom reported, current researches mentioning concentrate on individual values. We aimed investigate whether level change of was associated incidence stroke.Sociodemographic, medical background, anthropometric laboratory information were retrospectively collected. Classification conducted using k-means clustering analysis. Logistic regressions determine relationship different classes in taking class smallest as a reference. Meanwhile, restricted cubic spline regression applied examine links cumulative stroke.369 (7.8%) 4710 participants had stroke during 3 years. Compared 1 best control Index, OR for 2 good 1.427 (95% CI, 1.051-1.938), moderate 1.714 1.245-2.359), 4 worse 1.814 1.257-2.617), 5 consistently high levels 2.161 1.446-3.228). However, after adjusting multiple factors, only still an association (OR 1.430, 95%CI, 1.022-2.000). linear regression. In subgroup analysis, similar results shown without diabetes or dyslipidemia. There is neither additive nor multiplicative interaction covariates.A constant higher worst indicated risk stroke.