Cumulative exposure to high remnant-cholesterol concentrations increases the risk of cardiovascular disease in patients with hypertension: a prospective cohort study

• DOI: 10.1186/s12933-023-01984-4
• Publication Date: 2023-09-21T18:02:12Z
• Authors: Weiqiang Wu; Guanzhi Chen; Kuangyi Wu; Huancong Zheng; Yanjuan Chen; Xianxuan Wang; Zegui Huang; Zefeng Cai; Zhiwei Cai; Zhichao Chen; Yulong Lan; Shuohua Chen; Shouling Wu; Youren Chen
• Keywords: Interquartile range; Quartile; Angiology; Stroke

Abstract Background The relationship of cumulative remnant-cholesterol (Cum-RC) concentration with the risk cardiovascular disease (CVD) in patients hypertension remains unclear. Methods We studied data for 28,698 individuals whom three consecutive total cholesterol, high-density lipoprotein-cholesterol (HDL-C), and triglyceride concentrations were available, who did not have CVD (14,349 14,349 without), that was collected between 2006 2010. Participants placed into four groups based on Cum-RC quartile: a Q1 group (< 26.40 mg/dl), Q2 (26.40–39.56 Q3 (39.57–54.65 Q4 (≥ 54.66 mg/dl). Cox proportional hazards models used to evaluate CVD. Results Over median 10.9 (interquartile range, 10.5–11.3) years, 1,444 participants developed After adjustment multiple potential confounding factors, compared hypertension, adjusted hazard ratios Q2–Q4 1.07(0.92,1.26), 1.08(0.91,1.28), 1.26(1.03,1.54) ( P = 0.0405); those myocardial infarction 1.51(1.00,2.31), 2.02(1.22,3.27), 2.08(1.41,3.28) < 0.0001); ischemic stroke 1.02(0.84,1.24), 1.04(0.86,1.25), 1.29(1.02,1.62), respectively 0.0336). However, no significant found hemorrhage stroke. At same Cum-RC, significantly higher than without. Conclusions A consistently high increases hypertension. Therefore, achievement blood pressure RC targets should help reduce