Triglyceride-glucose index is associated with severe obstructive coronary artery disease and atherosclerotic target lesion failure among young adults

• DOI: 10.1186/s12933-023-02004-1
• Publication Date: 2023-10-21T13:02:20Z
• Authors: Shalaimaiti Shali; Lingfeng Luo; Kang Yao; Xiangdong Sun; Hongyi Wu; Shuning Zhang; Lili Xu; Wei Gao; Jianxuan Li; Juying Qian; Yan Zheng; Yuxiang Dai; Junbo Ge; ; Shalaimaiti Shali; Lingfeng Luo; Kang Yao; Xiangdong Sun; Hongyi Wu; Shuning Zhang; Lili Xu; Wei Gao; Jianxuan Li; Juying Qian; Yan Zheng; Yuxiang Dai; Junbo Ge
• Keywords: Angiology

Early diagnosis and treatment effectiveness of early-onset coronary artery disease (EOCAD) are crucial, non-invasive predictive biomarkers needed for young adults. We aimed to evaluate the usefulness triglyceride-glucose (TyG) index, a novel marker insulin resistance, in identifying CAD patients predicting their risk developing target lesion failure (TLF).We recruited EOCAD (luminal narrowing ≥ 70%) controls free from < 30%), both aged 45 years or younger, 38 hospitals China between 2017 2020. who underwent successful percutaneous intervention were followed incident TLF. TyG index was defined as Ln [fasting triglyceride (mg/dL) × fasting blood glucose (mg/dL)/2]. used logistic regression Cox proportional hazards modeling association with prevalent TLF, respectively. The discriminatory ability assessed by area under receiver-operating characteristic curve (AUC).Among included 1513 (39.6 ± 4.4 years, 95.4% male) age-matched (39.0 46.4% male), positively associated prevalence (adjusted odds ratio: 1.40, 95% confidence interval [CI] 1.23-1.60, per standard deviation [SD] increase index). addition an empirical model provided improvement diagnostic EOCAD, net reclassification 0.10 (95% CI 0.03-0.17, p = 0.005). During medium 33 month (IQR: 31-34 months) follow-up, 43 (3.3%) experienced Multivariate revealed that independent factor TLF hazard ratio [HR]: 2.410, 1.07-5.42 comparing top bottom tertile groups; HR: 1.30, 1.01-1.73, SD Compared conventional factors alone, modestly improved AUC (0.722-0.734, 0.04) predict TLF.TyG is appeared be valuable component future efforts improve stratification outcome prediction among