Coronary inflammation based on pericoronary adipose tissue attenuation in type 2 diabetic mellitus: effect of diabetes management

• DOI: 10.1186/s12933-024-02199-x
• Publication Date: 2024-03-29T18:02:06Z
• Authors: Yuankang Liu; Lisong Dai; Yue Dong; Cong Ma; Panpan Cheng; Cuiping Jiang; Hongli Liao; Ying Li; Xiang Wang; Xiangyang Xu
• Keywords: Angiology; Circumflex

Abstract Background Coronary inflammation plays crucial role in type 2 diabetes mellitus (T2DM) induced cardiovascular complications. Both glucose-lowering drug interventions (GLDIS) and glycemic control (GC) status potentially correlate coronary inflammation, as indicated by changes pericoronary adipose tissue (PCAT) attenuation, thus influence risk. This study evaluated the impact of GLDIS GC on PCAT attenuation T2DM patients. Methods retrospective collected clinical data computed tomography angiography (CCTA) images 1,342 patients, including 547 patients 795 non-T2DM two tertiary hospitals. were subgroup based criteria: (1) status: well: HbA1c < 7%, moderate: 7 ≤ 9%, poor: > 9%; (2) non-GLDIS. attenuations left anterior descending artery (LAD-PCAT), circumflex (LCX-PCAT), right (RCA-PCAT) measured. Propensity matching (PSM) was used to cross compare all subgroups Linear regressions conducted evaluate Results Significant differences observed RCA-PCAT LCX-PCAT between poor GC-T2DM (LCX: − 68.75 ± 7.59 HU vs. – 71.93 7.25 HU, p = 0.008; RCA: 74.37 8.44 77.2 7.42 0.026). Higher LAD-PCAT, LCX-PCAT, non-GLDIS compared with (LAD: 78.11 8.01 75.04 8.26 0.022; LCX: 71.10 8.13 68.31 7.90 0.037; 78.17 8.64 73.35 9.32 0.001). In linear regression, other than sex duration diabetes, both metformin acarbose found be significantly associated lower LAD-PCAT (metformin: β coefficient 2.476, =0.021; acarbose: 1.841, 0.031). Conclusion Inadequate management, lack GLDIS, may increased CCTA, leading finding could help healthcare providers identify risk, develop improved management programs, reduce subsequent related mortality.