Retrospective evaluation of the effectiveness of indoor residual spray with pirimiphos‐methyl (Actellic) on malaria transmission in Zambia

• DOI: 10.1186/s12936-021-03710-5
• Publication Date: 2021-04-01T16:03:07Z
• Authors: Joseph Keating; Joshua O. Yukich; John M. Miller; Sara Scates; Busiku Hamainza; Thomas P. Eisele; Adam Bennett
• Keywords: Indoor residual spraying

Abstract Background Widespread insecticide resistance to pyrethroids could thwart progress towards elimination. Recently, the World Health Organization has encouraged use of non-pyrethroid insecticides reduce spread resistance. An electronic tool for implementing and tracking coverage IRS campaigns recently been tested (mSpray), using satellite imagery improve accuracy efficiency enumeration process. The purpose this paper is retrospectively analyse cross-sectional observational data provide evidence epidemiological effectiveness having introduced Actellic 300CS mSpray platform into programmes across Zambia. Methods facility catchment areas in 40 high burden districts 5 selected provinces were initially targeted spraying. was used 7 Luapula Province. study design assess relationship between exposure confirmed malaria case incidence. A random effects Poisson model quantify effect (with without platform) on incidence over period 2013–2017; analysis restricted 4 where conducted each year 2014–2016. Results 283 health from 2014 2016; 198 facilities same provinces, that received no during period, served as a comparison. appears be associated with reduced incidence; rate ratio (IRR) lower but mSpray, compared (IRR = 0.91, 95% CI 0.84–0.98). Receiving significantly lowered 0.75, 0.66–0.86) IRS. resulted 0.83, 0.72–0.95). Conclusions Actellic-CS substantially programme, possibly through improved population level coverage. results lend credence anecdotal 3GIRS Actellic, importance exploring new platforms improving effective