The study of metabolic improvement by nutritional intervention controlling endogenous GIP (Mini Egg study): a randomized, cross-over study

• DOI: 10.1186/s12937-019-0472-0
• Publication Date: 2019-09-02T19:03:23Z
• Authors: Naoki Sakane; Noriko Osaki; Hideto Takase; Junko Suzuki; Chika Suzukamo; Shinsuke Nirengi; Akiko Suganuma; Akira Shimotoyodome
• Keywords: Peptide YY; Clinical nutrition; Gastric inhibitory polypeptide; Crossover study

Given the major role of glucose-dependent insulinotropic polypeptide (GIP) in regulation adiposity, this study examined effects induced by a diet based on Japanese tradition (SMART WASHOKU) visceral fat area (VFA) and GIP secretions.Overweight/obese men (n = 21; mean age, 41.0 ± 9.0 years; BMI, 25.2 2.0 kg/m2) without diabetes were placed either SMART WASHOKU or control meal for 2 weeks, randomized, cross-over setup with four-week washout period.For tolerance test, blood samples collected at 0, 30, 60, 120, 180, 240 min post-meal, followed measuring glucose, insulin, GIP, glucagon-like peptide-1 (GLP-1) levels. Relative to meal, yielded significantly lower plasma postprandial concentrations (AUC: 700.0 208.0 vs. 1117.0 351.4 pmol/L・4 h, P < 0.05); however, between meals, there was no significant difference levels GLP-1, peptide YY, ghrelin. Compared intervention reduced VFA LDL-cholesterol, triglyceride, HbA1c after chronic intervention.In conclusion, may decrease improve metabolic parameters overweight/obese men, possibly via suppressing secretion.