Dietary inflammatory index, risk of incident hypertension, and effect modification from BMI

• DOI: 10.1186/s12937-020-00577-1
• Publication Date: 2020-06-25T08:02:38Z
• Authors: Conor-James MacDo...; Nasser Laouali; Anne-Laure Madika; Francesca Romana ...; Marie-Christine B...
• Keywords: Clinical nutrition

Abstract Introduction Previous studies have identified a positive association between the inflammatory potential of diet and hypertension. It is not known if BMI an effect modifier for this association, nor dose-respondent. This study aimed to assess dietary index (DII) risk hypertension, any modification from BMI. Methods Data E3N cohort study, French prospective population-based initiated in 1990 was used. From women we included those who completed detailed history questionnaire, did prevalent hypertension or cardiovascular disease at baseline, resulting 46,652 women. The adapted DII assessed with data questionnaire. Hypertension cases were self-reported verified through drug-reimbursement database. Cox proportional hazard models used calculate ratios. Spline regression determine dose-respondent relationship. Results During 884,267 person-years, 13,183 incident identified. median population slightly pro-inflammatory (DII = + 0.44). A highly > 3.0) associated slight increase (HR Q1-Q5 1.07 [1.02, 1.13]). Evidence observed BMI, associations strongest amongst 18.5–21.0 range 1.17 [1.06, 1.29]). weak relationship observed. Conclusion Associations stronger healthy-lean