Small dense low density lipoprotein-cholesterol and cholesterol ratios to predict arterial stiffness progression in normotensive subjects over a 5-year period

• DOI: 10.1186/s12944-018-0671-2
• Publication Date: 2018-02-12T13:15:20Z
• Authors: Gang Li; Hui-kun Wu; Xiao-wei Wu; Zhe Cao; Yuan-chao Tu; Yi Ma; Wei-qing Wang; Jian Cheng; Zi-hua Zhou
• Keywords: Adult; Male; sdLDL-C; RC620-627; Pulse Wave Analysis; Cholesterol ratios; 03 medical and health sciences; Vascular Stiffness; 0302 clinical medicine; Risk Factors; Humans; Nutritional diseases. Deficiency diseases; Triglycerides; Research; Cholesterol, HDL; Cholesterol, LDL; Middle Aged; Arterial stiffness; 3. Good health; Carotid Arteries; Cholesterol; Cardiovascular Diseases; Female; Normotensive

Small dense low density lipoprotein-cholesterol (sdLDL-C), cholesterol ratios and carotid-femoral pulse wave velocity (cf-PWV) impart risk for all-cause morbidity mortality independently of conventional cardiovascular disease (CVD) factors. This study was designed to identify feasible indicators predicting arterial stiffness progression.We followed up 816 normotensive participants without diabetes or CVD nearly 5.0 years. Cholesterol parameters, other clinical laboratory data were collected at baseline. cf-PWV measured baseline the end follow-up.PWV progression subjects had higher levels PWV sdLDL-C TG/HDL-C ratio. significantly correlated with all parameters. Multiple regression models showed that closely associated follow-up (β = 0.222, p < 0.001) △PWV 0.275, 0.001). only one (OR 2.070, 95%CI: 1.162 3.688, 0.014) 1.355, 1.136 1.617, could determine after correction covariates. High sd-LDL-C quantiles more likely develop than (Tertiles 3 vs Tertiles1, RR 2.867, 1.106 7.434, 0.03).We founded ratio can predict in subjects, high level a stiffness.