Predictive value of TG/HDL-C and GFR-adjusted uric acid levels on cardiovascular mortality: the URRAH study

• DOI: 10.1186/s12944-025-02440-w
• Publication Date: 2025-01-24T09:41:06Z
• Authors: Elisa Russo; Francesca Viazzi; Roberto Pontremoli; Fabio Angeli; Carlo Maria Barba...; Bruno Berardino; Michele Bombelli; Federica Cappelli; Edoardo Casiglia; Rosario Cianci; Michele Ciccarelli; Arrigo F. G. Cicero; Massimo Cirillo; Pietro Cirillo; Lanfranco D’Elia; Giovambattista De...; Claudio Ferri; Ferruccio Galletti; Loreto Gesualdo; Cristina Giannatt...; Guido Grassi; Guido Iaccarino; Egidio Imbalzano; Luciano Lippa; Francesca Mallamaci; Alessandro Maloberti; Stefano Masi; Maria Masulli; Alberto Mazza; Alessandro Mengozzi; Maria Lorenza Mui...; Pietro Nazzaro; Paolo Palatini; Gianfranco Parati; Fosca Quarti-Trevano; Marcello Rattazzi; Gianpaolo Reboldi; Giulia Rivasi; Massimo Salvetti; Valerie Tikhonoff; Giuliano Tocci; Andrea Ungar; Paolo Verdecchia; Agostino Virdis; Massimo Volpe; Claudio Borghi
• Keywords: Lipidology; Clinical nutrition; Value (mathematics)

Insulin resistance (IR) and serum uric acid (SUA) are closely interconnected: SUA contributes to adversely affects the insulin signaling pathway IR, while IR is a known predictor for development of hyperuricemia. The triglyceride (TG) high-density lipoprotein cholesterol (HDL-C) ratio has been proposed as an easily obtainable marker IR. This research aimed investigate interaction between glomerular filtration rate (GFR)-adjusted uricemia (SUA/GFR ratio) in determining CV risk large population cohort study. Data from 18,694 subjects were analyzed Uric Right foR heArt Healt (URRAH) database. study evaluated association TG/HDL-C SUA/GFR ratio, well their impact on outcomes during follow-up period. primary endpoint was mortality. After mean 124 ± 64 months, 2,665 (14.2%) deaths occurred. incidence fatal non-fatal events increased parallel with increase quintiles. showed positive increasing even non-diabetic patients. Multivariate analysis that increases mortality after adjustment potential confounding factors. Finally, GFR-adjusted hyperuricemia additive effect Both independently predict mortality, regardless age, gender, BMI, diabetes, hypertension statin use. joint elevated greater than presence each single factor highlights importance monitoring these markers better assess cardiovascular risk.