Reactive oxygen species (ROS)-responsive nanoprobe for bioimaging and targeting therapy of osteoarthritis

• DOI: 10.1186/s12951-021-01136-4
• Publication Date: 2021-11-27T10:02:28Z
• Authors: Chong Shen; Ming Gao; Haimin Chen; Yanting Zhan; Qiumei Lan; Zhimin Li; Wei Xiong; Zainen Qin; Li Zheng; Jinmin Zhao
• Keywords: Nanoprobe

Stimulus-responsive therapy that allows precise imaging-guided is limited for osteoarthritis (OA) due to the selection of proper physiological markers as stimulus. Based on over-production Reactive Oxygen Species (ROS) associated with progression in OA, we selected ROS and designed a cartilage targeting ROS-responsive theranostic nanoprobe can be used effective bioimaging OA. This was fabricated by using PEG micelles modified ROS-sensitive thioketal linkers (TK) cartilage-targeting peptide, termed TKCP, which then encapsulated Dexamethasone (DEX) form TKCP@DEX nanoparticles. Results showed smartly "turn on" response excessive off" normal joint. By applying different doses inducer inhibitor, this emit ROS-dependent fluorescence according degree OA severity, helpful disease classification clinic. Specifically cartilage, could effectively respond sustained release DEX remarkably reduce damage joints. smart, sensitive endogenously activated promising theranostics.