A thermoreversible antibacterial zeolite-based nanoparticles loaded hydrogel promotes diabetic wound healing via detrimental factor neutralization and ROS scavenging

• DOI: 10.1186/s12951-021-01151-5
• Publication Date: 2021-12-11T10:02:34Z
• Authors: Yao Qi; Kun Qian; Jin Chen; Yifeng E; Yijie Shi; Hongdan Li; Liang Zhao
• Keywords: Male; 0301 basic medicine; Poloxamer; Diabetes Mellitus, Experimental; Rats, Sprague-Dawley; Mice; 03 medical and health sciences; Medical technology; Human Umbilical Vein Endothelial Cells; Animals; Humans; R855-855.5; Cells, Cultured; Chitosan; Wound Healing; Zeolite; Research; Temperature; Hydrogels; Free Radical Scavengers; Anti-Bacterial Agents; 3. Good health; Hydrogel; RAW 264.7 Cells; Zeolites; Nanoparticles; Reactive oxygen species; Reactive Oxygen Species; Pluronic F127; TP248.13-248.65; Biotechnology

Abstract Background As recovery time of diabetic wound injury is prolonged by the production detrimental factors, including reactive oxygen species (ROS) and inflammatory cytokines, attenuating oxidative stress reactions in microenvironment site would be significant. Experimental design In our study, we prepared thermoreversible, antibacterial zeolite-based nanoparticles loaded hydrogel to promote healing via neutralization factors such as cytokines ROS. Results The cerium (Ce)-doped biotype Linde type A (LTA) zeolite synergistically eliminated mitochondrial ROS neutralized free thus remodeling anti-inflammatory enhancing angiogenesis. Moreover, thermoreversible composed Pluronic F127 chitosan demonstrated strong haemostatic bactericidal behavior. Conclusions conclusion, obtained antibacterial, hydrogels represent a multi-targeted combination therapy for healing. Graphical