A novel multifunctional microneedle patch for synergistic photothermal- gas therapy against maxillofacial malignant melanoma and associated skin defects

• DOI: 10.1186/s12951-024-02409-4
• Publication Date: 2024-04-23T05:01:28Z
• Authors: Shaojie Dong; Yuwei Zhang; Yifei Zhang; Yukun Mei; Ahmadi Sina; Rui Zou; Lin Niu
• Keywords: Nitroprusside; Skin Neoplasms; Photothermal Therapy; Ultraviolet Rays; Iron; Apoptosis; Maxillofacial malignant melanoma; Nitric Oxide; Mice; 03 medical and health sciences; Cell Line, Tumor; Medical technology; Animals; Humans; R855-855.5; Melanoma; Skin; 0303 health sciences; Research; Skin defect; Microneedle; Photothermal therapy; Gas therapy; Needles; TP248.13-248.65; Biotechnology

Considering the high recrudescence and long-lasting unhealed large-sized wound that affect aesthetics cause dysfunction after resection of maxillofacial malignant skin tumors, a groundbreaking strategy is urgently needed. Photothermal therapy (PTT), which has become complementary treatment however, powerless in tissue defect regeneration. Therefore, novel multifunctional sodium nitroprusside Fe