An overview of the role of Niemann-pick C1 (NPC1) in viral infections and inhibition of viral infections through NPC1 inhibitor

• DOI: 10.1186/s12964-023-01376-x
• Publication Date: 2023-12-14T15:02:36Z
• Authors: Irfan Ahmad; Seyede Narges Fatemi; Mohammad Ghaheri; Ali Rezvani; Dorsa Azizi Khezri; Mohammad Natami; Saman Yasamineh; Omid Gholizadeh; Zahra Bahmanyar
• Keywords: NPC1

Abstract Viruses communicate with their hosts through interactions proteins, lipids, and carbohydrate moieties on the plasma membrane (PM), often resulting in viral absorption via receptor-mediated endocytosis. Many viruses cannot multiply unless host’s cholesterol level remains steady. The large endo/lysosomal protein (MP) Niemann-Pick C1 (NPC1), which is involved cellular transport, a crucial intracellular receptor for infection. NPC1 ubiquitous housekeeping essential controlled efflux from lysosomes. Its human absence results type C disease, deadly lysosomal storage disorder. an host component filovirus entrance, infection, pathogenesis. For NPC1’s function unnecessary. Furthermore, blocking limits entry replication of African swine fever virus by disrupting homeostasis. Cell entrance quasi-enveloped variants hepatitis A E has also been linked to NPC1. By controlling levels, necessary effective release reovirus cores into cytoplasm. Drugs that limit activity are against several viruses, including SARS-CoV Type I Feline Coronavirus (F-CoV). These findings reveal as potential therapeutic target treating illnesses demonstrate its significance infections. This article provides synopsis infections review inhibitors may be used counteract Graphical