Emerging strategies for treating autoimmune disease with genetically modified dendritic cells

• DOI: 10.1186/s12964-024-01641-7
• Publication Date: 2024-05-07T09:01:54Z
• Authors: Yunhan Ma; Ruobing Shi; Fujun Li; Haocai Chang
• Keywords: Genetically engineered

Abstract Gene editing of living cells has become a crucial tool in medical research, enabling scientists to address fundamental biological questions and develop novel strategies for disease treatment. This technology particularly revolutionized adoptive transfer cell therapy products, leading significant advancements tumor treatment offering promising outcomes managing transplant rejection, autoimmune disorders, inflammatory diseases. While recent clinical trials have demonstrated the safety tolerogenic dendritic (TolDC) immunotherapy, concerns remain regarding its effectiveness. review aims discuss application gene techniques enhance tolerance function (DCs), with particular focus on preclinical that are currently being investigated optimize phenotype DCs. We explore potential approaches vitro generation TolDCs provide an overview emerging modifying Additionally, we highlight primary challenges hindering adoption TolDC therapeutics propose future research directions this field.