Aberrant activation of TGF-β/ROCK1 enhances stemness during prostatic stromal hyperplasia

• DOI: 10.1186/s12964-024-01644-4
• Publication Date: 2024-05-06T10:02:03Z
• Authors: Youyou Li; Jiaren Li; Liang Zhou; Zhenxing Wang; Ling Jin; Jia Cao; Hui Xie; Long Wang
• Keywords: ROCK1

Abstract Benign prostatic hyperplasia (BPH) is a multifactorial disease in which abnormal growth factor activation and embryonic reawakening are considered important factors. Here we demonstrated that the aberrant of transforming β (TGF-β)/Rho kinase 1 (ROCK1) increased stemness BPH tissue by recruiting mesenchymal stem cells (MSCs), indicating role BPH. When TGF-β/ROCK1 abnormally activated, MSCs recruited differentiate into fibroblasts/myofibroblasts, leading to prostate stromal hyperplasia. Further research showed inhibition ROCK1 suppressed MSC migration their potential for differentiation. Collectively, our findings suggest regulates cell lineage specificity, small molecule inhibitor GSK269962A could target may be treatment Graphical