Both HDAC5 and HDAC6 are required for the proliferation and metastasis of melanoma cells

• DOI: 10.1186/s12967-015-0753-0
• Publication Date: 2016-01-08T12:56:43Z
• Authors: Jiaqi Liu; Jianying Gu; Zihao Feng; Yanhong Yang; Ningwen Zhu; Weiyue Lu; Fazhi Qi
• Keywords: Histone deacetylase 5; HDAC6; Vorinostat

Histone deacetylase (HDAC) inhibitors are widely used in clinical investigation as novel drug targets. For example, panobinostat and vorinostat have been to treat patients with melanoma. However, HDAC small-molecule compounds without a specific target, their mechanism of action is unclear. Therefore, it necessary investigate which HDACs required for the proliferation metastasis melanoma cells. We overexpression knocking down lentivirus clarify influence HDAC5 HDAC6 development. Also, we introduced stable or knockdown cells into null mice found that were unable form solid tumors. Finally, tested expression sub-location tissues tumor adjacent tissues. In this study, highly expressed but exhibited low levels normal skin Furthermore, knocked A375 demonstrated both contributed This study cell through different signaling pathways.