Relationship between mismatch repair immunophenotype and long-term survival in patients with resected periampullary adenocarcinoma

• DOI: 10.1186/s12967-018-1444-4
• Publication Date: 2018-03-14T13:03:20Z
• Authors: Margareta Heby; Sebastian Lundgren; Björn Nodin; Jacob Elebro; Jakob Eberhard; Karin Jirström
• Keywords: Periampullary cancer; Tissue microarray; Immunophenotyping

Periampullary adenocarcinomas, including pancreatic cancer, are a heterogeneous group of tumors with poor prognosis, where classification into intestinal type (I-type) or pancreatobiliary (PB-type) is relevant prognostic factor. The clinical significance deficient mismatch repair (dMMR) in periampullary adenocarcinoma comparatively unexplored. Herein, we examined the associations MMR immunophenotype long-term survival patients resected adenocarcinoma, particular reference to morphology and adjuvant treatment response.MMR protein expression was assessed by immunohistochemistry on tissue microarrays primary from retrospective cohort 175 treated pancreaticoduodenectomy during 2001-2011 Malmö Lund University Hospitals, Sweden. Cox proportional hazards models were applied calculate hazard ratios (HR) 95% confidence intervals (CI).After mean follow-up 46.5 (1.9-185.1) months, 35 (20.3%) alive, 24 I-type 11 PB-type tumors. could be evaluated 172 cases, which dMMR denoted 20 (11.6%) 13/63 (20.6%) 7/109 (6.4%) associated significantly prolonged overall entire (HR = 0.28, CI 0.13-0.57), 0.20, 0.06-0.68), however not independent conventional factors. In tumors, prognostic, but there significant negative interaction between (pinteraction 0.015).dMMR more frequent compared factor for only former. finding small number potentially lacking benefit chemotherapy noteworthy merits further validation.