C-reactive protein derived from perivascular adipose tissue accelerates injury-induced neointimal hyperplasia

• DOI: 10.1186/s12967-020-02226-x
• Publication Date: 2020-02-11T12:02:52Z
• Authors: Jia-Yuan Chen; Xiao-Lin Zhu; Wen-Hao Liu; Yong Xie; Hai-Feng Zhang; XiaoQiao Wang; Ru Ying; Zhi-Teng Chen; Mao-Xiong Wu; Qiong Qiu; Jing-Feng Wang; Yang-Xin Chen
• Keywords: Neointimal hyperplasia; Infiltration (HVAC); Adipose tissue macrophages; Monocyte

Abstract Aim Inflammation within the perivascular adipose tissue (PVAT) in obesity plays an important role cardiovascular disorders. C-reactive protein (CRP) level patients is significantly increased and associated with occurrence progression of disease. We tested hypothesis CRP derived from PVAT contributes to vascular remodeling after injury. Methods A high-fat diet (HFD) expression PVAT. transplanted thoracic aortic wild-type (WT) or transgenic CRP-expressing (CRPTG) mice injured femoral artery WT mice. Results At 4 weeks injury, neointimal/media ratio was that received CRPTG compared Transplanted also accelerated adventitial macrophage infiltration vasa vasorum proliferation. It revealed greater than adhesion rate monocytes through receptor Fcγ RI. Proteome profiling showed over-expression promoted chemokine (C-X-C motif) ligand 7 (CXCL7) tissue, transwell assay monocyte migration indirectly via induction CXCL7 adipocytes. Conclusion HFD neointimal hyperplasia