Adiponectin suppresses tumor growth of nasopharyngeal carcinoma through activating AMPK signaling pathway

• DOI: 10.1186/s12967-022-03283-0
• Publication Date: 2022-02-14T12:03:03Z
• Authors: Zongmeng Zhang; Jinlin Du; Hui Shi; Shuai Wang; Yunjing Yan; Qihua Xu; Sujin Zhou; Zhenggang Zhao; Yunping Mu; Chaonan Qian; Allan Zijian Zhao; Sumei Cao; Fanghong Li
• Keywords: Adiponectin receptor 1

Adiponectin is an adipocyte-secreted cytokine that enhances insulin sensitivity and attenuates inflammation. Although circulating adiponectin level often inversely associated with several malignancies, its role in the development of nasopharyngeal carcinoma (NPC) remains unclear. Here, we investigated clinical association between NPC, examined impact adiponectin, as well underlying mechanisms, on NPC growth both vitro vivo.