Tumor immune dysfunction and exclusion subtypes in bladder cancer and pan-cancer: a novel molecular subtyping strategy and immunotherapeutic prediction model

• DOI: 10.1186/s12967-024-05186-8
• Publication Date: 2024-04-17T15:02:22Z
• Authors: Kun Zheng; Youlong Hai; Hongqi Chen; Yukun Zhang; Xiaoyong Hu; Kai Ni
• Keywords: Subtyping; Immune escape

Molecular subtyping is expected to enable precise treatment. However, reliable strategies for clinical application remains defective and controversial. Given the significance of tumor immune dysfunction exclusion (TIDE), we aimed develop a novel TIDE-based strategy guide personalized immunotherapy in bladder cancer (BC).