Clinical features and characteristics of uveitis associated with juvenile idiopathic arthritis in Japan: first report of the pediatric rheumatology association of Japan (PRAJ)

• DOI: 10.1186/s12969-019-0318-5
• Publication Date: 2019-04-11T13:32:30Z
• Authors: Junko Yasumura; Masato Yashiro; Nami Okamoto; Kosuke Shabana; Hiroaki Umebayashi; Naomi Iwata; Yuka Okura; Tomohiro Kubota; Masaki Shimizu; Minako Tomiita; Yasuo Nakagishi; Kenichi Nishimura; Ryoki Hara; Mao Mizuta; Takahiro Yasumi; Fumiya Yamaide; Hiroyuki Wakiguchi; Masao Kobayashi; Masaaki Mori
• Keywords: Oligoarthritis; Juvenile rheumatoid arthritis; Rheumatoid factor

Although there are many reports on Juvenile Idiopathic arthritis-associated uveitis (JIA-U) from various countries, especially Europe and North America, few Asia. Our aim was to investigate the epidemiology, characteristics predictors of JIA-U in Japan.Data were retrospectively collected 726 patients with JIA medical records as April 2016 at 15 centers specialized pediatric rheumatic diseases. Of these, further investigated for specific this manifestation.The prevalence 6.1% examined. Incidence significantly higher an earlier arthritis onset (2.6-vs.-5.8 years, P < 0.0001), oligoarthritis (16.1%-vs.-1.6%, 0.001), or anti-nuclear antibodies. On contrary, it less common rheumatoid factor anti-cyclic citrullinated peptide A history using methotrexate (MTX), infliximab adalimumab also associated occurrence. The median age diagnosis 5 time 2 years. occurrence anterior bilateral 79.3 53.7%, respectively. There no symptoms 58.5% cases. Complications arising between last observation increased 31.7 56.1%; particular, cataract 3-fold. While lost their vision, 61.9% did not recover normal vision (≥ 1.0), cases active persisted, males. In addition steroid eye drops (97.6%) MTX (15.4%), biological agents used treating 41.5% patients.The Japan described here first time. is lower than predominantly Caucasian cohorts, reported America Europe, found be similar.