Early ficolin-1 is a sensitive prognostic marker for functional outcome in ischemic stroke

• DOI: 10.1186/s12974-016-0481-2
• Publication Date: 2016-01-20T15:20:59Z
• Authors: R. Zangari; E. R. Zanier; G. Torgano; A. Bersano; S. Beretta; E. Beghi; B. Casolla; N. Checcarelli; S. Lanfranconi; A. Maino; C. Mandelli; G. Micieli; F. Orzi; E. Picetti; M. Silvestrini; N. Stocchetti; B. Zecca; P. Garred; M. G. De Simoni
• Keywords: Ficolin; Stroke; Pathogenesis; Lectin pathway

Several lines of evidence support the involvement lectin pathway complement (LP) in pathogenesis acute ischemic stroke. The aim this multicenter observational study was to assess prognostic value different circulating LP initiators Plasma levels ficolin-1, -2, and -3 mannose-binding (MBL) were measured 80 stroke patients at 6 h only 85 48 later. Sixty-one age- sex-matched healthy individuals served as controls. Stroke severity on admission using National Institutes Health Scale (NIHSS). outcome 90 days by modified Rankin (mRS). Ficolin-1 decreased compared with controls (median 0.13 vs 0.33 μg/ml, respectively, p < 0.0001). At h, ficolin-1 significantly higher (0.45 0.0001) samples Likewise, ficolin-2 (2.70 4.40 but not h. Ficolin-3 both (17.3 18.23 21.5 0.001 <0.05, respectively). For MBL no difference detected between or within time points. In multivariate analysis, early independently associated unfavorable mRS (adjusted odds ratio (OR): 2.21, confidence interval (CI) 95 % 1.11–4.39, = 0.023). Early improved discriminating ability an model including NIHSS age (area under curve (AUC) 0.95, CI 0.90–0.99, ficolins are consumed after implicating activation LP. is selectively related 3-month outcome.