NK cells control HIV‐1 infection of macrophages through soluble factors and cellular contacts in the human decidua

• DOI: 10.1186/s12977-016-0271-z
• Publication Date: 2016-06-06T12:25:25Z
• Authors: H. Quillay; H. El Costa; M. Duriez; R. Marlin; C. Cannou; Y. Madec; C. de Truchis; M. Rahmati; F. Barré-Sinoussi; M. T. Nugeyre; E. Menu
• Keywords: Decidua

During the first trimester of pregnancy, HIV-1 in utero transmission is rare despite permissivity placenta and decidua (the uterine mucosa during pregnancy) to infection. In from macrophages (dMs) are main target cells. Decidual natural killer (dNK) cells account for 70 % decidual leukocytes. They display distinct phenotype functions compared peripheral NK At periphery, involved control this study, we investigate whether human dM infection.Autologous cocultures infected dMs with dNK reveal that strongly inhibit The addition at different times after infection suggests occurs before complete establishment Double chamber show cellular contacts necessary an optimal Nevertheless, soluble factors secreted by double partially infection, indicating have also a role IFN-γ secretion increased uninfected cocultures. We cells.These results demonstrate efficiently vitro, highlight innate immune determinants transmission.