Moderate- to high intensity aerobic and resistance exercise reduces peripheral blood regulatory cell populations in older adults with rheumatoid arthritis

• DOI: 10.1186/s12979-020-00184-y
• Publication Date: 2020-05-16T06:02:43Z
• Authors: Sofia E. M. Ander...; Elvira Lange; Daniel Kucharski; Sara Svedlund; Karin Önnheim; Maria Bergquist; Elisabet Josefsson; Janet M. Lord; Inga-Lill Mårtensson; Kaisa Mannerkorpi; Inger Gjertsson
• Keywords: Aerobic Exercise; Regulatory T cell

Exercise can improve immune health and is beneficial for physical function in patients with rheumatoid arthritis (RA), but the immunological mechanisms are largely unknown. We evaluated effect of moderate- to high intensity exercise person-centred guidance on cells system, focus regulatory cell populations, older adults RA.Older (≥65 years) RA were randomized either 20-weeks moderate - aerobic resistance (n = 24) or an active control group performing home-based light 25). Aerobic capacity, muscle strength, DAS28 CRP evaluated. Blood samples collected at baseline after 20 weeks. The frequency defined as adaptive CD4 + Foxp3 CD25 CD127- T (Tregs) CD19 CD24hiCD38hi B (Bregs) well HLA-DR-/lowCD33 CD11b myeloid derived suppressor (MDSCs), assessed using flow cytometry.After weeks exercise, capacity strength significantly improved there no significant changes Disease Activity Score 28 (DAS28) CRP. Tregs Bregs decreased intervention group, not group. had MDSCs. reduction was most pronounced female patients.Moderate- led a proportion Bregs, that associated increased disease activity inflammation.Improved Ability Cope With Everyday Life Through Person-centered Training Program Elderly Patients Rheumatoid Arthritis PEP-walk Study, NCT02397798. Registered ClinicalTrials.gov March 19, 2015.