The impact of circadian rhythms on the immune response to influenza vaccination in middle-aged and older adults (IMPROVE): a randomised controlled trial

• DOI: 10.1186/s12979-022-00304-w
• Publication Date: 2022-10-17T05:02:42Z
• Authors: Yihao Liu; Hui Zhang; Gang Yuan; Mi Yao; Bin Li; Jianying Chen; Yuling Fan; Ruohui Mo; Fenghua Lai; Xinwen Chen; Mengyuan Li; Binfeng Chen; Janet M. Lord; Sui Peng; KarKeung Cheng; Haipeng Xiao
• Keywords: Immunosenescence; Antibody titer

Vaccination is important in influenza prevention but the immune response wanes with age. The circadian nature of system suggests that adjusting time vaccination may provide an opportunity to improve immunogenicity. Our previous cluster trial Birmingham suggested differences between morning and afternoon for some strains vaccine older adults. Whether this effect also seen a younger age group less likelihood compromised immunity unknown. We therefore conducted individual-based randomized controlled Guangzhou test hypothesis induces stronger adults than vaccination. included middle determine if was groups.Of 418 participants randomised, 389 (93.1%, 191 middle-aged aged 50-60 years 198 65-75 years) were followed up. Overall, there no significant difference antibody titers (geometric mean /95% CI) after vs (A/H1N1: 39.9 (32.4, 49.1) vs. 33.0 (26.7, 40.7), p = 0.178; A/H3N2: 92.2 (82.8, 102.7) 82.0 (73.8, 91.2), 0.091; B: 15.8 (13.9, 17.9) 14.4 (12.8, 16.3), 0.092), respectively. However, pre-specified subgroup analyses, post-vaccination versus (A/H1N1): 49.5 (36.7, 66.6) 32.9 (24.7, 43.9), 0.050; (A/H3N2): 93.5 (80.6, 108.5) 73.1 (62.9, 84.9), 0.021; (B): 16.6 (13.8, 20.1) (12.3, 17.0), 0.095, Among females, 46.9 (35.6, 61.8) 31.1 (23.8, 0.030; 96.0 (83.5, 110.3) 84.7 (74.4, 96.5), 0.176; 14.8 (12.7, 17.3) 13.0 (11.3, 14.9), 0.061, In old males, vaccination.Morning enhance immunogenicity over 65 women. An intervention modify programs vaccinate individuals simple, cost free feasible most health systems.