Encephalitis associated with human herpesvirus-7 infection in an immunocompetent adult
Adult
Male
0301 basic medicine
Roseolovirus Infections
Case Report
Herpesvirus 7, Human
Infectious and parasitic diseases
RC109-216
Immunocompetent adults
Clinical significance HHV-7 CNS infection, Human herpesvirus-7 encephalitis, Immunocompetent adults
Human herpesvirus-7 encephalitis
3. Good health
03 medical and health sciences
Clinical significance HHV-7 CNS infection
Humans
Encephalitis, Viral
Polyradiculopathy
DOI:
10.1186/s12985-017-0764-y
Publication Date:
2017-05-25T14:12:11Z
AUTHORS (8)
ABSTRACT
Primary Human herpesvirus-7 (HHV-7) infection usually occurs during childhood and causes several clinical manifestations: mainly exanthem subitum (roseola infantum), followed by a lifelong latent state with possible reactivation in case of immunodeficiency. Nevertheless, some considerably different approaches exist regarding the natural history of HHV-7 and the possible consequences of HHV-7 infection in immunocompetent adults. In particular, little is known about its pathogenic role in central nervous system (CNS) disease in nonimmunosuppressed adults. Specifically, in case of encephalitis, it is important to distinguish between infectious encephalitis and postinfectious encephalomyelitis for the management of patients CASE PRESENTATION: We describe here a case of encephalitis associated to human herpesvirus-7 with associated polymyeloradiculopathy in an immunocompetent patient which may contribute to the delineation of the approach to a patient profile with a similar clinical presentation and evolution to those presented in the literature.This case may alert clinicians to consider this specific etiology in the differential diagnosis of encephalopathy in patients with suspected infectious encephalitis who do not respond to acyclovir or in patients who develop acute polymyeloradiculopathy, considering that HHV-7 may be a pathological factor and that a timely diagnosis is crucial for the early administration of specific treatment.
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