Diagnostic value of miR-186-5p for carotid artery stenosis and its predictive significance for future cerebral ischemic event

• DOI: 10.1186/s13000-020-01007-w
• Publication Date: 2020-07-30T11:28:24Z
• Authors: Weibo Lv; Tao Zhang; Hongwei Zhao; Shuang He; Bingwei Li; Yang Gao; Wenying Pan
• Keywords: Male; Asymptomatic CAS; Research; Middle Aged; Prognosis; Sensitivity and Specificity; Cerebral ischemic events; Brain Ischemia; 3. Good health; MiR-186-5p; MicroRNAs; 03 medical and health sciences; 0302 clinical medicine; Diagnosis; Pathology; RB1-214; Humans; Carotid Stenosis; Female; Biomarkers; Aged

Abstract Background MicroRNAs (miRNAs) serve as novel promising biomarkers for the diagnosis and prognosis of many human diseases. This study investigated diagnostic value miR-186-5p asymptomatic carotid artery stenosis (CAS), its predictive future cerebral ischemic events (CIEs). Methods Sixty-seven cases with CAS 60 healthy individuals were recruited. Serum levels tested by using qRT-PCR. Receiving–operator characteristic (ROC) curve was drawn based on sensitivity specificity analyses. All followed up 5 years. Kaplan-Meier method applied evaluation occurrence CIE. Results The serum level increased significantly in patients. MiR-186-5p most significant factor associated high degree In ROC analysis, AUC 0.919, 89.6% 81.7% at cutoff 1.221. results revealed that CIEs. High independent factors Conclusion serves a potential biomarker patients CAS, predicts