Expressions of TWIST1 and CD105 markers in colorectal cancer patients and their association with metastatic potential and prognosis

• DOI: 10.1186/s13000-021-01088-1
• Publication Date: 2021-03-22T07:03:03Z
• Authors: Fahimeh Fattahi; Leili Saeednejad ...; Somayeh Vafaei; Zohreh Habibi Shams; Jafar Kiani; Marzieh Naseri; Elmira Gheytanchi; Zahra Madjd
• Keywords: Tissue microarray

Abstract Background TWIST1 and CD105, which contribute to tumor malignancy, are overexpressed in cancers. Accordingly, enhances epithelial-to-mesenchymal transition (EMT) promotes the formation of cancer stem cells (CSCs). Also, CD105 is a neoangiogenesis marker endothelial cells, introduced as CSC tumoral epithelial several types The present study was aimed investigate expressions colorectal (CRC) patients. Methods Expressions 250 CRC tissue samples were evaluated using immunohistochemistry on microarrays (TMAs). In this regard, expression investigated subcellular locations (cytoplasm nucleus), while mapped cytoplasmic tissues. association between these markers clinicopathological parameters, well survival outcomes analyzed. Results indicate statistically significant higher nuclear levels distant metastases ( P = 0.040) addition, it shown that increased had poor prognostic value for disease-specific (DSS) progression-free (PFS) 0.042, 0.043, respectively) patients with CRC. Moreover, analysis level has revealed there more advanced TNM stage 0.050). Conclusions Our results demonstrate associations aggressive behavior diseases cases.