Dosimetric feasibility of 4DCT-ventilation imaging guided proton therapy for locally advanced non-small-cell lung cancer

• DOI: 10.1186/s13014-018-1018-x
• Publication Date: 2018-04-25T08:31:40Z
• Authors: Qijie Huang; Salma K. Jabbour; Zhiyan Xiao; Ning Yue; Xiao Wang; Hongbin Cao; Yu Kuang; Yin Zhang; Ke Nie
• Keywords: Image registration

The principle aim of this study is to incorporate 4DCT ventilation imaging into functional treatment planning that preserves high-functioning lung with both double scattering and scanning beam techniques in proton therapy. Eight patients locally advanced non-small-cell cancer were included study. Deformable image registration was performed for each patient on their 4DCTs the resultant displacement vector field Jacobian analysis used identify high-, medium- low-functional regions. Five plans designed patient: a regular photon IMRT vs. anatomic without consideration information using therapy (DSPT) intensity modulated (IMPT) avoidance high-functional DSPT IMPT. Dosimetric parameters compared terms tumor coverage, plan heterogeneity, normal tissues. Our results showed IMPT gave superior dose advantage IMRTs sparing low regions total V5 (volume receiving 5Gy). only marginal benefit or V20 20Gy) anatomical plans. Yet, delivery, can further reduce degrading PTV dosimetric coverages, planning. Although doses some critical organs might increase during planning, necessary constraints all met. Incorporating feasible. plans, are effective preserve coverage.