Evolution of radiation-induced temporal lobe injury after intensity-modulated radiation therapy in nasopharyngeal carcinoma: a large cohort retrospective study

• DOI: 10.1186/s13014-024-02400-1
• Publication Date: 2024-01-19T06:02:34Z
• Authors: Jing Hou; Yun He; Handong Li; Zhaodong Ai; Qiang Lu; Biao Zeng; Chuanmiao Xie; Xiaoping Yu
• Keywords: Nasopharyngeal Carcinoma; Intensity-modulated radiotherapy; Research; R895-920; Neoplasms. Tumors. Oncology. Including cancer and carcinogens; Nasopharyngeal Neoplasms; Magnetic Resonance Imaging; Temporal Lobe; Cohort Studies; Medical physics. Medical radiology. Nuclear medicine; 03 medical and health sciences; Magnetic resonance imaging; 0302 clinical medicine; Nasopharyngeal carcinoma; Humans; Temporal lobe injury; Radiation Injuries; RC254-282; Retrospective Studies

Abstract Background Previous studies have demonstrated conflicting findings regarding the initial MRI patterns of radiotherapy-induced temporal lobe injury (RTLI) and evolution different RTLI patterns. The aim this study was to evaluate pattern in patients with nasopharyngeal carcinoma (NPC) by means a large cohort study. Methods Data were retrospectively collected from two hospitals between January 2011 December 2021. injured lobes categorized into three based on patterns: isolated white matter lesions (WMLs), contrast-enhanced (CELs), combined WMLs CELs. latency period, appearances, changes CELs evaluated. Results A total 913 1092 included numbers WMLs, CELs, identified at first detection 7 (0.6%), 172 (15.8%), (83.6%), respectively. bilateral same patient, that unilateral also may occur asynchronously. time intervals last negative scan 8.6, 8.9 11.0 months, significant difference observed (H = 14.287, P 0.001). And interval as an independent factor influencing after Poisson regression ( 0.002). Conclusion Both could be only abnormalities RTLI. This is great significance accurately diagnosing early providing timely treatment options. Additionally, it provides clinical evidence for guidelines NPC, emphasizing importance regular follow-up NPC patients.