Associations between serum calcium, 25(OH)D level and bone mineral density in older adults

• DOI: 10.1186/s13018-019-1517-y
• Publication Date: 2019-12-21T12:02:29Z
• Authors: Minbo Liu; Xiaocong Yao; Zhongxin Zhu
• Keywords: Cross-sectional study; Subgroup analysis

Calcium and vitamin D play important roles in bone health as essential nutrients. We explored whether serum calcium, 25(OH)D were associated with mineral density (BMD) older adults.This cross-sectional study was conducted on a sample of 4595 participants (2281 men 2314 women) aged ≥ 50 years (from to 85 years, 60.1 ± 8.7 for 62.0 9.7 from the National Health Nutrition Examination Survey (NHANES) 2001-2006. The independent variables calcium 25(OH)D. dependent variable lumbar BMD. other considered potential effect modifiers. performed weighted multivariate linear regression models smooth curve fittings evaluate associations between them. Subgroup analyses also performed.We observed negative association BMD fully adjusted model. In subgroup analyses, this no longer significant among males race/ethnicity. On hand, there positive did not differ different age groups, women. However, followed U-shaped Mexican Americans.This indicated that negatively correlated BMD, positively adults. curve.