Time-dependent changes of plasma inflammatory biomarkers in type A aortic dissection patients without optimal medical management

• DOI: 10.1186/s13019-014-0199-0
• Publication Date: 2015-01-15T17:03:19Z
• Authors: Jun Gu; Jia Hu; Hong-wei Zhang; Zheng-hua Xiao; Zhi Fang; Hong Qian; Ming-hua Zhong; Ying-qiang Guo; Er-yong Zhang; Ying-kang Shi; Wei Meng
• Keywords: Cardiothoracic surgery; Vascular surgery

To investigate the time-dependent changes in plasma levels of interleukin-6, C-reactive protein, and tumor necrosis factor-α patients with type A aortic dissection (TAAD) who received unoptimal medical management since onset dissections.Plasma were detected by ELISA immuno-turbidimetric assay 92 TAAD at hospital admission. Blood samples from 78 uncontrolled hypertension 82 healthy volunteers also analyzed as controls. The occurrence TAAD-related complication its relationship these inflammatory biomarkers was investigated.The concentrations mediators significant higher than those group. time to peak level IL-6.and TNF-α shorter that CRP In group, 51 suffered complications, their significantly without complications (94.5 ± 58.8 mg/L versus 47.4 47.8 mg/L, p < 0.001). Also, strongly correlated value PaO2/FiO2 ratio (r = -0.69, 0.001) creatinine 0.60, duration persistently high longer group complication-free group.Elevated CRP, IL-6 associated progressively development TAAD. changing pattern might be a marker for diagnosis prophylactic treatment complications. Our findings suggested critical role inflammation progression