Effect of ventilation strategy during cardiopulmonary bypass on postoperative pulmonary complications after cardiac surgery: a randomized clinical trial

• DOI: 10.1186/s13019-021-01699-1
• Publication Date: 2021-10-30T20:16:39Z
• Authors: Meng-Qiu Zhang; Yu-Qi Liao; Hong Yu; Xue-Fei Li; Wei Shi; Wei-Wei Jing; Zai-Li Wang; Yi Xu; Hai Yu
• Keywords: Cardiothoracic surgery

Abstract Background To determine whether maintaining ventilation during cardiopulmonary bypass (CPB) with a different fraction of inspired oxygen (FiO 2 ) had an impact on the occurrence postoperative pulmonary complications (PPCs). Methods A total 413 adult patients undergoing elective cardiac surgery CPB were randomly assigned into three groups: 138 in NoV group (received no mechanical CPB), LOV tidal volume (V T 3–4 ml/kg ideal body weight respiratory rate 10–12 bpm, and positive end-expiratory pressure 5–8 cmH O CPB; FiO was 30%), 137 HOV same parameters settings as while 80%). Results The primary outcomes incidence severity PPCs hospitalization. composite did not significantly differ between (63%), (49%) (57%) groups ( P = 0.069). And there also difference regarding non-ventilation (NoV) (the combination HOV) groups. observed lower proportion moderate severe (grade ≥ 3) than (23.1% vs. 44.2%, 0.001). Conclusion Maintaining reduce surgery. Trial registration : Chinese Clinical Registry ChiCTR1800015261. Prospectively registered 19 March 2018. http://www.chictr.org.cn/showproj.aspx?proj=25982