Effect of ventilation strategy during cardiopulmonary bypass on postoperative pulmonary complications after cardiac surgery: a randomized clinical trial
Adult
Cardiopulmonary Bypass
Postoperative pulmonary complications
RD1-811
Cardiopulmonary bypass
Cardiac surgery
Respiration, Artificial
3. Good health
03 medical and health sciences
Mechanical ventilation
0302 clinical medicine
Anesthesiology
Tidal Volume
Humans
Fraction of inspired oxygen
Surgery
RD78.3-87.3
Cardiac Surgical Procedures
Lung
Research Article
DOI:
10.1186/s13019-021-01699-1
Publication Date:
2021-10-30T20:16:39Z
AUTHORS (9)
ABSTRACT
Abstract
Background
To determine whether maintaining ventilation during cardiopulmonary bypass (CPB) with a different fraction of inspired oxygen (FiO2) had an impact on the occurrence of postoperative pulmonary complications (PPCs).
Methods
A total of 413 adult patients undergoing elective cardiac surgery with CPB were randomly assigned into three groups: 138 in the NoV group (received no mechanical ventilation during CPB), 138 in the LOV group (received a tidal volume (VT) of 3–4 ml/kg of ideal body weight with the respiratory rate of 10–12 bpm, and the positive end-expiratory pressure of 5–8 cmH2O during CPB; the FiO2 was 30%), and 137 in the HOV group (received the same ventilation parameters settings as the LOV group while the FiO2 was 80%).
Results
The primary outcomes were the incidence and severity of PPCs during hospitalization. The composite incidence of PPCs did not significantly differ between the NoV (63%), LOV (49%) and HOV (57%) groups (P = 0.069). And there was also no difference regarding the incidence of PPCs between the non-ventilation (NoV) and ventilation (the combination of LOV and HOV) groups. The LOV group was observed a lower proportion of moderate and severe pulmonary complications (grade ≥ 3) than the NoV group (23.1% vs. 44.2%, P = 0.001).
Conclusion
Maintaining ventilation during CPB did not reduce the incidence of PPCs in patients undergoing cardiac surgery.
Trial registration: Chinese Clinical Trial Registry ChiCTR1800015261. Prospectively registered 19 March 2018. http://www.chictr.org.cn/showproj.aspx?proj=25982
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